Download PDF World of Warcraft: WolfheartBy Richard A. Knaak

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World of Warcraft: WolfheartBy Richard A. Knaak

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In the wake of the Cataclysm, conflict has engulfed every corner of Azeroth. Hungering for more resources amid the turmoil, the Horde has pressed into Ashenvale to feed its burgeoning war machine. There, acting warchief Garrosh Hellscream has employed a brutal new tactic to conquer the region and crush its night elf defenders, a move that will cripple the Alliance’s power throughout the World of Warcraft.

Unaware of the disaster brewing in Ashenvale, the night elves’ legendary leaders, High Priestess Tyrande Whisperwind and Archdruid Malfurion Stormrage, conduct a summit near Darnassus in order to vote the proud worgen of Gilneas into the Alliance. However, resentment of Gilneas and its ruler, Genn Greymane, runs deep in Stormwind’s King Varian Wrynn. His refusal to forgive Genn for closing his nation off from the rest of the world years ago endangers more than just the summit: it threatens to unravel the Alliance itself.

Varian’s animosity is only one of many unsettling developments in Darnassus. An uneasiness creeps over the once-immortal night elves as the first of them fall victim to the infirmities of age. While they cope with their mortality, tensions flare over the reintroduction of the Highborne, formerly the highest caste of night elf nobility, into their society. Many night elves are unable to pardon the Highborne for the destruction unleashed on Azeroth millennia ago by their reckless use of magic.

When a murdered Highborne is discovered on the outskirts of Darnassus, Malfurion and Tyrande move to stop further bloodshed and unrest by appointing one of the night elves’ most cunning and skilled agents to find the killer: the renowned warden Maiev Shadowsong. Yet with all that is transpiring in Darnassus, the Alliance might be powerless to stop the relentless new warchief Garrosh from seizing the whole of Ashenvale.

• Sales Rank: #76238 in eBooks
• Published on: 2011-09-13
• Released on: 2011-09-13
• Format: Kindle eBook

About the Author
Richard A. Knaak is the New York Times bestselling author of some three dozen novels, including the The Sin War trilogy for Diablo and the Legend of Huma for Dragonlance. He has penned the War of the Ancients trilogy, Day of the Dragon and its upcoming followup, Night of the Dragon. His other works include his own Dragonrealm series, the Minotaur Wars for Dragonlance, the Aquilonia trilogy of the Age of Conan, and the Sunwell Trilogy -- the first Warcraft manga. In addition, his novels and short stories have been published worldwide in such diverse places as China, Iceland, the Czech Republic, and Brazil. 

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Ebook Download The Essential Ian McHarg: Writings on Design and Nature

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Will be shipped from US. Brand new copy.

• Published on: 1656
• Binding: Paperback

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Ebook Download Antibiotics: Actions, Origins, Resistance

Ebook Download Antibiotics: Actions, Origins, Resistance

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Antibiotics: Actions, Origins, Resistance

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Product details

Hardcover: 335 pages

Publisher: ASM Press; 1 edition (February 11, 2003)

Language: English

ISBN-10: 1555812546

ISBN-13: 978-1555812546

Product Dimensions:

7.2 x 1 x 10 inches

Shipping Weight: 1.8 pounds

Average Customer Review:

5.0 out of 5 stars

4 customer reviews

Amazon Best Sellers Rank:

#1,930,347 in Books (See Top 100 in Books)

Walsh's `Antibiotics' is a great introduction to the major classes of antibiotics and how each works, or doesn't, against cells, including not only bacteria but fungi and cancer cells. Each class of antibiotic is described, with step-by-step explanations of the chemical mechanics of the antibiotic on its target. The author discusses the growing problem of bacterial resistance to antibiotics and what steps are being taken, in terms of new drug development and new schemes for existing drug use, to overcome this problem.This was a very satisfying read. The information is dense but the author's style is reader-friendly and concise. The text is supported by many illustrations of the mechanics being described and these illustrations are detailed and explicit. I wanted an up-to-date, fairly technical book about antibiotic function and this book fit the bill better than I could have hoped. I look forward to going back to Walsh's book again for an even better understanding.

Legendary among natural product chemists, Christopher Walsh takes us through the detailed mechanisms of the biosynthetic pathways which common classes of antibiotics target. This is a valuable reference book because it allows us to see why antibiotics work on an atom-by-atom basis--something which most microbiology texts are incapable of doing. A strong background in organic chemistry is required to really understand the mechanisms outlined in the text, but coupled with an undergraduate organic textbook, this book is superior introduction to the overlapping worlds of medicinal, organic, and biosynthetic chemistry.

Christopher Walsh is a great chemist and a great writer alike; Dr. Timothy Wencewicz was also my favorite professor, and he collaborated on it. Really made me appreciate antibiotic chemistry.

This book was written by the eminent biochemist Christopher Walsh, whose broad research interests include the study of antibiotic action and resistance. It is extremely well written and organized, with an abundance of excellent illustrations. The approach is to give the reader an in depth but not exhausting coverage of several key topics in modern antibiotic research. Both novice and seasoned researcher will find much of value within the pages of this modest sized book. This important work is published at a period in time in which the resistance of a broad range of pathogenic bacteria to antibiotics has grown to alarming levels. At the same time, many pharmaceutical companies have recently abandoned research and development of new antibiotic agents.Walsh starts the book with a brief chapter on fundamental antibiotic concepts. Where do antibiotics come from? How do they work? How does resistance develop? He next launches into a thorough review of the main classes of antibiotics, interweaving antibiotic chemical structures and targets of the drugs with the underlying microbial physiology processes that are targeted. He begins with the various classes of bacterial cell wall inhibitors, emphasizing the members of the large beta-lactam class, as well as glycopeptides and moenomycin. Next he delves into the multiple classes of protein synthesis inhibitors. He makes full use of the latest structural data emerging from X-ray crystallography of ribosomal subunits, to illustrate the mechanisms of drug action. He covers the macrolides, tetracyclines, and aminoglycosides, as well as the new glycylcyclines and oxazolidinones. The DNA topoisomerases are next featured as targets, and the interactions of quinolone antibiotics with DNA gyrase and topoisomerase. This chapter was a bit short and sparse in some details as compared to the preceding chapters, but does hit the main highlights. A final chapter in this section addresses other antibiotic classes such as the folate metabolism antagonists (sulfa drugs and trimethoprim), as well as peptide antibiotics.The next section addresses the many mechanisms of antibiotic resistance. These four chapters examine different types of mechanisms employed by bacteria to evade antibiotics. Succinct coverage of the broad range of beta-lactamases and the aminoglycoside modifying (inactivating) enzymes are found in a chapter on enzymatic destruction or modification of antibiotics. This is followed by a very nice summary chapter around antibiotic efflux pumps, which again incorporates some structural biology. Unfortunately, the book was published just prior to the latest crystallographic studies of the RND class AcrB pump, which has added much to our understanding of efflux pumps. The final resistance chapter highlights target modification or replacement. The methicillin resistance story in Staphylococcus, mediated by PBP2a, is detailed, as is the resistance mediated by the mosaic PBP genes in pneumococci. Macrolide resistance by ribosomal methylation and the fascinating story of vancomycin resistance by the restructuring the terminal D-alanine dipeptide target is covered (Walsh's laboratory was a major contributor to the vancomycin story).The next section of the book deals with the biosynthesis of antibiotics by producing organisms, primarily Streptomyces species. These chapters interweave the genetics and biochemistry of secondary metabolism. The signaling pathways used among producer organisms, as well as the gene regulation of the individual antibiotic biosynthetic genes, which are clustered on the chromosome are discussed. There is a chapter on each on polyketide antibiotic synthesis (erythromycins and tylosin) and non-ribosomal synthesis of peptide antibiotics (penicillins, bacitracin, vancomycin).The book ends with 3 chapters on identifying new antibiotics. A survey of targets, both "old" and new is presented, and several suggestions for novel ways to interfere with bacterial function are briefly reviewed. Another chapter examines identifying new chemical entities with antibacterial properties. The initial part of the chapter emphasizes combinatorial chemistry approaches. Unfortunately, this process to date has led to only sparse results, with some inhibitors identified. As Walsh notes, the conversion of a chemical inhibitor of an antibacterial enzyme target to a lead compound that can be subsequently endowed with all the myriad pharmacological properties necessary to be a drug is an extremely daunting task. The vast majority of compounds identified cannot be successfully modified to possess the properties necessary to be a drug. A second approach that he covers, the modification by genetic means of antibiotic producing organisms to synthesize new antibiotics (combinatorial biosynthesis), may be more promising.Walsh closes out the book with some thought provoking chapters around the proper use of antibiotics, and strategies to minimize resistance development. He highlights the antibiotic resistant pathogens of the 21st century, and the continued problem of methicillin resistant staphylococci and vancomycin resistant enterococci. He makes it abundantly clear that there has been no victory in the fight against infectious diseases, and the reports from the front lines are less than encouraging for the future.

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Download Ebook Principles of ChemistryBy Michael Munowitz

Download Ebook Principles of ChemistryBy Michael Munowitz

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Principles of ChemistryBy Michael Munowitz

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"Can Munowitz write or what!" exclaimed one advance reviewer of this extraordinary new text.

Read a few pages, and you'll see what all the excitement is about. Intended primarily for college freshmen, this exceptionally lucid, carefully paced, elegantly designed, well-illustrated volume will appeal to curious readers of any age who want to know more about the innermost workings of the "central science." In the words of another advance reviewer, the Munowitz book "reveals the beauty of chemistry in an unusual, graceful, narrative style. Compared with standard textbooks, it is poetic." This book is unusual in several respects. Perhaps the most obvious, at first glance, is the distinctive pattern of white and gray stripes that appear when you view its pages edge-on. The striped pattern is a superficial manifestation of a novel's internal structure. Unlike a standard chemistry textbook, in which each chapter is fragmented into a hodgepodge of disparate parts--text, boxed features, worked exercises, solved and unsolved problems, in-chapter and end-of-chapter summaries, miscellaneous decorative elements-- each chapter in Principles of Chemistry has a much simpler organization: an uninterrupted narrative core (white pages), followed by a Review and Guide to Problems section (gray pages). In short: principles first, then practice. The tutorial, problem-solving sections at the ends of the chapters amount, in effect, to a built-in study guide, thus obviating the need for a separate volume of this type. In addition, the long run of predominantly white pages at the back of the book consists, for the most part, of an unusually complete set of appendices devoted to such important matters as nomenclature, mathematics, assorted tables, and a glossary. Taken just by themselves, then, the white pages that constitute the first, narrative parts of the book's 21 chapters add up to a fairly modest-sized book-within-a-book-- at least by comparison with other texts for the introductory general chemistry course. And what a book it is! As the reviewers' comments quoted elsewhere attest, the novel intrachapter organization of the Munowitz text contributes to another of this book's distinctive features: its remarkably coherent "story line." The main driving force here, though, is the extraordinary power and clarity of the author's writing by far the most remarked-upon special attribute of this book. Just crack it open anywhere and start reading, and you'll see what all the fuss is about.

• Sales Rank: #106880 in Books
• Brand: Unknown
• Published on: 1999-07-17
• Ingredients: Example Ingredients
• Original language: English
• Number of items: 1
• Dimensions: 10.40" h x 2.20" w x 7.70" l, 5.55 pounds
• Binding: Hardcover
• 1616 pages

Features

• Used Book in Good Condition

Review
Can Munowitz write or what! His hortatory, grab-'em-by-the-scruff-of-the-neck-and-don't-let-go-until-they-get-it style is great! It moves along and is not boring. Here is an author with enthusiasm and a point of view. The problems are even interesting I worked some out myself just for the fun of it. -- John J. Alexander, University of Cincinnati

I particularly like the author's very careful and detailed discussions of the physical mechanisms behind the various equations that he presents. I know of no introductory textbook in which this is done as well. -- Colin MacKay, Haverford College

If I wanted a student to learn the material on his or her own, I'd hand them Munowitz. -- Robert Cave, Harvey Mudd College

Relegating the 'gritty practicality' to the review and problems section at the end of the chapter makes possible a more focused and seamless introduction to the concepts, which makes possible more engaging writing. The extended summary allows repetition and recapitulation of the concepts, which I think may enhance retention of the material. Clustering the problems and using an engaging 'dialogue' to introduce and relate them helps the students see a scientist's thinking modeled. -- Michael Fuson, Denison University

The text reveals the beauty of chemistry in an unusual, graceful narrative style. Compared to standard textbooks, it is poetic.... The presentation of problems is unusual and particularly attractive.... By postponing instruction on problems until the end of the chapter, Munowitz avoids interruptions in the compelling narrative and invites undivided attention to the problems when they are addressed. The concise power of Munowitz's writing is most evident in the Introduction, which tells what chemistry is better than any other text I know. -- Henry Griffin, University of Michigan

This is an amazing book. It's not just beautifully written or perfectly accurate or entrancing to read, although it is all that. What is more important is that it practices what it describes, namely the scientific search for truth. Munowitz's attention to the exact meanings of individual words mirrors a similar scrupulousness with respect to the macroscopic structure--the book. The effect is as captivating as a suspense novel. I have simply never come across a chemistry text so well written . . .. It is well known that most incoming freshmen who intend to major in science change their minds in the first year, probably because of the massive tedium of introductory curricula. Many manage to pass only by rote memorization of words that have no meaning for them--mass, force, energy, etc. This book has the capacity to change that. -- Edward T. Samulski, University of North Carolina

[The Munowitz text] takes a principles-driven approach that displays the unity and coherence of the physical sciences by emphasizing the relationship between microscopic structure and macroscopic properties. The author writes with a crisp, direct, no nonsense, yet polished style. The analogies are appropriate, the imagery vivid, and the science accurate.... The book represents a paradigm shift and promises to be the text for the next millennium. -- James Harrison, Michigan State University

About the Author
Michael Munowitz is a full-time science writer. A graduate of Yale University, he earned a Ph.D. in chemical physics from Harvard University and has held postdoctoral appointments at the University of Leiden and the University of California, Berkeley. He is the author most recently of Principles of
Chemistry, described by one reviewer as "the best-written general chemistry book I have ever read." He lives in Naperville, Illinois.

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